William M Armstead Selected Research

Nociceptin

2/2011	Nociceptin/orphanin phenylalanine glutamine (FQ) receptor and cardiovascular disease.
1/2006	Differential activation of ERK, p38, and JNK MAPK by nociceptin/orphanin FQ in the potentiation of prostaglandin cerebrovasoconstriction after brain injury.
8/2005	NOC/oFQ activates ERK and JNK but not p38 MAPK to impair prostaglandin cerebrovasodilation after brain injury.
10/2004	NMDA and age dependent cerebral hemodynamics after traumatic brain injury.
2/2004	Nociceptin/orphanin FQ alters prostaglandin cerebrovascular action following brain injury.
2/2003	Newborn pig nociceptin/orphanin FQ activates protein tyrosine kinase and mitogen activated protein kinase to impair NMDA cerebrovasodilation after ischemia.
1/2003	PTK, MAPK, and NOC/oFQ impair hypercapnic cerebrovasodilation after hypoxia/ischemia.
12/2002	Role of Nociceptin/Orphanin FQ in the physiologic and pathologic control of the cerebral circulation.
10/2002	Age-dependent NOC/oFQ contribution to impaired hypotensive cerebral hemodynamics after brain injury.
8/2002	Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.

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William M Armstead Research Topics

Disease

34	Brain Injuries (Brain Injury) 12/2019 - 07/2002
22	Traumatic Brain Injuries (Traumatic Brain Injury) 11/2020 - 12/2002
20	Hypotension (Low Blood Pressure) 01/2018 - 11/2002
12	Stroke (Strokes) 01/2019 - 09/2006
12	Ischemia 02/2014 - 05/2002
11	Hypoxia (Hypoxemia) 02/2014 - 05/2002
10	Necrosis 01/2019 - 03/2016
7	Hypercapnia 01/2012 - 01/2003
6	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2012 - 12/2002
3	Brain Ischemia (Cerebral Ischemia) 12/2019 - 10/2005
3	Ischemic Stroke 01/2019 - 04/2010
3	Intracranial Hypertension 09/2010 - 05/2009
2	Brain Hypoxia (Cerebral Hypoxia) 02/2014 - 03/2009
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 11/2013 - 04/2010
1	COVID-19 04/2021
1	Inflammation (Inflammations) 01/2019
1	Lung Diseases (Lung Disease) 11/2018
1	Hyperglycemia 03/2011
1	Craniocerebral Trauma (Head Injury) 03/2011
1	Cardiovascular Diseases (Cardiovascular Disease) 02/2011
1	Central Nervous System Diseases (CNS Diseases) 07/2010
1	Brain Neoplasms (Brain Tumor) 04/2010
1	Glioma (Gliomas) 04/2010
1	Neoplasms (Cancer) 04/2010

Drug/Important Bio-Agent (IBA)

16	Mitogen-Activated Protein KinasesIBA 01/2019 - 07/2002
16	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2019 - 09/2004
12	N-Methylaspartate (NMDA)IBA 01/2019 - 08/2002
10	U 0126 (UO 126)IBA 05/2012 - 01/2003
10	NociceptinIBA 02/2011 - 08/2002
9	Endothelin-1 (Endothelin 1)IBA 01/2019 - 01/2003
9	Phosphotransferases (Kinase)IBA 01/2019 - 03/2009
7	Adenosine Triphosphate (ATP)IBA 01/2019 - 07/2002
7	salicylhydroxamic acid (SHAM)IBA 01/2018 - 05/2002
7	Plasminogen Activators (Plasminogen Activator)IBA 07/2012 - 05/2005
6	ProstaglandinsIBA 07/2012 - 11/2002
6	Opioid Analgesics (Opioids)IBA 01/2006 - 08/2002
5	Interleukin-6 (Interleukin 6)IBA 11/2019 - 03/2016
5	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2019 - 11/2002
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 09/2004
5	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 03/2016 - 08/2003
5	p38 Mitogen-Activated Protein KinasesIBA 11/2013 - 08/2003
4	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 12/2019 - 05/2009
4	CalciumIBA 01/2019 - 07/2002
4	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2017 - 09/2010
4	Endothelins (Endothelin)IBA 01/2017 - 03/2011
4	SB 203580IBA 01/2016 - 08/2003
4	Peptides (Polypeptides)IBA 02/2014 - 07/2010
4	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 03/2009 - 09/2004
4	Superoxides (Superoxide)IBA 10/2004 - 08/2002
4	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2003 - 07/2002
3	PapaverineIBA 12/2019 - 11/2008
3	cyclo(Trp-Asp-Pro-Val-Leu)IBA 01/2019 - 05/2012
3	Pharmaceutical PreparationsIBA 01/2019 - 01/2018
3	Glutamic Acid (Glutamate)FDA Link 01/2016 - 03/2011
3	Proteins (Proteins, Gene)FDA Link 01/2016 - 02/2003
3	Dinoprostone (PGE2)FDA Link 07/2012 - 08/2005
3	JNK Mitogen-Activated Protein KinasesIBA 01/2012 - 01/2006
3	AdrenomedullinIBA 05/2010 - 10/2007
3	Protein Isoforms (Isoforms)IBA 01/2006 - 08/2003
3	Dizocilpine Maleate (Dizocilpine)IBA 10/2004 - 05/2002
3	GenisteinIBA 08/2003 - 01/2003
2	LMT-28IBA 01/2019 - 01/2019
2	pyrazolanthroneIBA 01/2018 - 01/2012
2	Epinephrine (Adrenaline)FDA LinkGeneric 10/2017 - 01/2017
2	Dopamine (Intropin)FDA LinkGeneric 09/2017 - 02/2013
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 10/2016 - 03/2016
2	ChloraloseIBA 02/2014 - 10/2005
2	ThromboxanesIBA 02/2014 - 01/2006
2	Glucagon (Glukagon)FDA Link 07/2012 - 03/2011
2	KATP ChannelsIBA 03/2012 - 02/2011
2	salvinorin AIBA 01/2012 - 01/2012
2	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2012 - 09/2008
2	Plasminogen InactivatorsIBA 08/2010 - 09/2006
2	Oxygen (Dioxygen)IBA 07/2005 - 07/2003
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 10/2004 - 08/2002
2	Angiotensin IIIBA 11/2003 - 11/2002
2	GTP-Binding Proteins (G-Protein)IBA 05/2003 - 01/2003
1	Therapeutic UsesIBA 11/2020
1	Propranolol (Inderal)FDA LinkGeneric 11/2019
1	Lipoproteins (Lipoprotein)IBA 01/2016
1	Immunoglobulin G (IgG)IBA 01/2016
1	PlasminogenIBA 01/2016
1	polyethylene glycol-superoxide dismutaseIBA 05/2012
1	kappa Opioid Receptors (kappa Opioid Receptor)IBA 01/2012
1	Protein Kinases (Protein Kinase)IBA 01/2012
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 03/2011
1	Endothelin Receptors (Endothelin Receptor)IBA 03/2011
1	ImmunosorbentsIBA 03/2011
1	EnzymesIBA 03/2011
1	clazosentanIBA 03/2011
1	Insulin (Novolin)FDA Link 03/2011
1	Phenylalanine (L-Phenylalanine)FDA Link 02/2011
1	Glutamine (L-Glutamine)FDA Link 02/2011
1	Potassium Channels (Potassium Channel)IBA 01/2011
1	Contrast MediaIBA 04/2010

Therapy/Procedure

4	Therapeutics 12/2019 - 05/2010
2	Thrombolytic Therapy 07/2010 - 08/2009
1	Critical Care (Surgical Intensive Care) 04/2021
1	Microspheres (Microsphere) 01/2016
1	Intravenous Injections 03/2011